Alessandro Di Spiezio Selected Research

Lysosomal-Associated Membrane Protein 1

1/2022	Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
1/2020	Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.

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Alessandro Di Spiezio Research Topics

Disease

3	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2022 - 01/2020
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 10/2021
1	Synucleinopathies 01/2022
1	Hypertrophy 01/2022
1	Retinal Degeneration 01/2022
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Weight Loss (Weight Reduction) 10/2021
1	Gliosis 10/2021
1	Obesity 01/2020
1	Blindness (Hysterical Blindness) 01/2020
1	Body Weight (Weight, Body) 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 01/2016

Drug/Important Bio-Agent (IBA)

3	Cathepsin BIBA 01/2022 - 01/2020
3	SaposinsIBA 01/2022 - 01/2020
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022 - 01/2020
3	Cathepsin DIBA 01/2022 - 01/2020
2	Phosphates (Orthophosphate)IBA 01/2022 - 01/2020
2	Lysosomal-Associated Membrane Protein 1IBA 01/2022 - 01/2020
2	Mannose (D-Mannose)IBA 01/2022 - 01/2020
2	Protein AggregatesIBA 10/2021 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 10/2021 - 01/2020
2	Cathepsin LIBA 10/2021 - 01/2020
2	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2020 - 01/2016
2	LeptinIBA 01/2020 - 01/2018
1	Retinaldehyde (Retinal)IBA 01/2022
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2022
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2022
1	IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA 01/2022
1	Polymethyl Methacrylate (Sol)IBA 01/2022
1	SynucleinsIBA 01/2022
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	EnzymesIBA 01/2022
1	coomassie Brilliant BlueIBA 01/2022
1	Amino Acids FDA Link 01/2022
1	Prion ProteinsIBA 01/2022
1	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 10/2021
1	BuffersIBA 01/2020
1	CeroidIBA 01/2020
1	Glial Fibrillary Acidic ProteinIBA 01/2020
1	LipofuscinIBA 01/2020
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020
1	Lysergic Acid Diethylamide (LSD)IBA 01/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Tripeptidyl-Peptidase 1IBA 01/2020
1	procathepsin DIBA 01/2020
1	LDL Receptors (LDL Receptor)IBA 01/2020
1	oxidized low density lipoproteinIBA 01/2020
1	Lysosomal-Associated Membrane Protein 2IBA 01/2020
1	Hormones (Hormone)IBA 01/2018
1	Amyloid (Amyloid Fibrils)IBA 01/2016

Therapy/Procedure

2	Enzyme Replacement Therapy 01/2022 - 01/2020